Author/Authors :
Takashi Owa، نويسنده , , Hiroshi Yoshino، نويسنده , , Tatsuo Okauchi، نويسنده , , Tadashi Okabe، نويسنده , , Yoichi Ozawa، نويسنده , , Naoko Hata Sugi، نويسنده , , Kentaro Yoshimatsu، نويسنده , , Takeshi Nagasu، نويسنده , , Nozomu Koyanagi، نويسنده , , Kyosuke Kitoh، نويسنده ,
Abstract :
We herein report the synthesis and antitumor activity of E7070 analogues containing a 3-pyridinesulfonamide moiety. E7070 was selected from our sulfonamide-based compound collections, currently undergoing Phase II clinical trials because of its tolerable toxicity profile and some antitumor responses in the Phase I setting. Of the analogues examined, ER-35745, a 6-amino-3-pyridinesulfonamide derivative, demonstrated significant oral efficacy against the HCT116 human colon carcinoma xenograft in nude mice.
