Title of article :
Identification of a novel 1′-[5-((3,5-Dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4′-bipiperidine) as a Dual NK1/NK2 antagonist
Author/Authors :
Pauline C. Ting، نويسنده , , Joe F. Lee، نويسنده , , Neng-Yang Shih، نويسنده , , John J. Piwinski، نويسنده , , John C. Anthes، نويسنده , , Richard W. Chapman، نويسنده , , Charles A. Rizzo، نويسنده , , John A. Hey، نويسنده , , Kwokei Ng، نويسنده , , Amin A. Nomeir، نويسنده ,
Abstract :
A novel series of dual NK1/NK2 receptor antagonists, based on the 2-oxo-(1,4′-bipiperidine) template, has been prepared. Compound 10R is a potent dual NK1/NK2 antagonist and demonstrates excellent in vivo activity and good oral plasma levels in the dog.
