Author/Authors :
James L. Toth، نويسنده , , Carly A. Price، نويسنده , , Erik C. Madsen، نويسنده , , Heather L. Handl، نويسنده , , Stephen J. Hudson، نويسنده , , Richard B. Hubbard III، نويسنده , , J. Phillip Bowen، نويسنده , , Konstantinos Kiakos، نويسنده , , John A. Hartley، نويسنده , , Moses Lee، نويسنده ,
Abstract :
Conjugates of racemic seco-cyclopropaneindoline-2-benzofurancarboxamide (CI-Bf) and four diamides (ImIm 1, ImPy 2, PyIm 3, and PyPy 4, where Py is pyrrole, and Im is imidazole), linked by a γ-aminobutyrate group were synthesized. In addition to alkylating at adenine-N3 positions within an A5 sequence, the imidazole-containing compounds 1 and 2 were found to also alkylate purine-N3 positions within a sequence 3′-GGGGG (888)CTGCTC(894)-5′. A model for the binding of hairpin conjugates 1 and 2 with the 3′-G CT-5′ sequence is proposed.
