Title of article
Quinoline-3-carbothioamides and related compounds as novel immunomodulating agents
Author/Authors
Takashi Tojo، نويسنده , , Glen W. Spears، نويسنده , , Kiyoshi Tsuji، نويسنده , , Hiroaki Nishimura، نويسنده , , Takashi Ogino، نويسنده , , Nobuo Seki، نويسنده , , Aiko Sugiyama، نويسنده , , Masaaki Matsuo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
2427
To page
2430
Abstract
A series of quinoline-3-carbothioamides and their analogues was prepared via four synthetic routes and evaluated for their antinephritic and immunomodulating activities. The optimal compound 9g strongly inhibited the T-cell independent antibody production in mice immunized with TNP-LPS and was highly effective in two nephritis models, namely chronic graft-versus-host disease and autoimmune MRL/l mice.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792465
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