Author/Authors :
Achyutharao Sidduri، نويسنده , , Jefferson W. Tilley، نويسنده , , Jian Ping Lou، نويسنده , , Li Chen، نويسنده , , Gerry Kaplan، نويسنده , , Frank Mennona، نويسنده , , Robert Campbell، نويسنده , , Robert Guthrie، نويسنده , , Tai-Nan Huang، نويسنده , , Karen Rowan، نويسنده , , Virginia Schwinge، نويسنده , , Louis M. Renzetti، نويسنده ,
Abstract :
A series of N-benzoyl-4-[(2,6-dichlorobenzoyl)amino]- -phenylalanine derivatives was prepared in order to optimize the substitution on the N-benzoyl moiety for VCAM/VLA-4 antagonist activity. Disubstitution in the 2- and 6-positions is favored and a range of small alkyl and halogen are tolerated. A model of the bioactive conformation of these compounds is proposed.
