Author/Authors :
Moorthy S. S. Palanki، نويسنده , , Leah M. Gayo-Fung، نويسنده , , Graziella I. Shevlin، نويسنده , , Paul Erdman، نويسنده , , Mark Sato، نويسنده , , Mark Goldman، نويسنده , , Lynn J. Ransone، نويسنده , , Cheryl Spooner، نويسنده ,
Abstract :
Several analogues of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate (1) were synthesized and tested as inhibitors of AP-1 and NF-κB mediated transcriptional activation in Jurkat T cells. From our SAR work, ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))-N-methylamino]-4-(trifluoromethyl)-pyrimidine-5-carboxylate was identified as a novel and potent inhibitor.
