Title of article
Synthesis and Characterization of a New RXR Agonist Based on the 6-tert-Butyl-1,1-dimethylindanyl Structure
Author/Authors
Beatriz Dom?nguez، نويسنده , , M. Jes?s Vega، نويسنده , , Fredy Sussman، نويسنده , , Angel R. de Lera، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
2607
To page
2609
Abstract
A new ligand for RXR is described, which is based on a 6-tert-butyl-1,1-dimethylindanyl skeleton as bioisostere of the hydrophobic retinoid region. The Stille cross-coupling reaction allowed the attachment of the polyene side chain to the indanyl ring. Docking studies were carried out to explain the RXR binding profile of this analogue.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792506
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