• Title of article

    Spirocyclic NK1 antagonists II: [4.5]-spiroethers

  • Author/Authors

    Brian J. Williams، نويسنده , , Margaret A. Cascieri، نويسنده , , Gary G. Chicchi، نويسنده , , Timothy Harrison، نويسنده , , Andrew P. Owens، نويسنده , , Simon N. Owen، نويسنده , , Nadia M. J. Rupniak، نويسنده , , David F. Tattersall، نويسنده , , Angela Williams، نويسنده , , Christopher J. Swain، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2002
  • Pages
    4
  • From page
    2719
  • To page
    2722
  • Abstract
    A series of novel spiroether-based neurokinin-1 (NK1) antagonists is described. The effect of modifications to the spiroether ring and aromatic substituents are discussed, leading to the identification of compounds with high affinity and excellent CNS penetration.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2002
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    792528

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=792528