Author/Authors :
Michael H. Serrano-Wu، نويسنده , , Denis R. St. Laurent، نويسنده , , Yijun Chen، نويسنده , , Stella Huang، نويسنده , , Kin-Ray Lam، نويسنده , , James A. Matson، نويسنده , , Charles E. Mazzucco، نويسنده , , Terry M. Stickle، نويسنده , , Thomas P. Tully، نويسنده , , Henry S. Wong، نويسنده , , Dolatrai M. Vyas، نويسنده , , Balu N. Balasubramanian، نويسنده ,
Abstract :
The synthesis and biological activity of sordarin oxazepine derivatives are described. The key step features a regioselective oxidation of an unprotected triol followed by double reductive amination to afford the ring-closed products. The spectrum of antifungal activity for these novel derivatives includes coverage of Candida albicans, Candida glabrata, and Cryptococcus neoformans.
