Title of article
Synthesis and Activity of a Novel Class of Tribasic Macrocyclic Antibiotics: The Triamilides
Author/Authors
Michael A. Letavic، نويسنده , , Brian S. Bronk، نويسنده , , Camilla D. Bertsche، نويسنده , , Jeffrey M. Casavant، نويسنده , , Hengmiao Cheng، نويسنده , , Kirsten L. Daniel، نويسنده , , David M. George، نويسنده , , Shigeru F. Hayashi، نويسنده , , Barbara J. Kamicker، نويسنده , , Nicole L. Kolosko، نويسنده , , Laura J. L. Norcia، نويسنده , , Vanessa D. Oberton، نويسنده , , Margaret A. Rushing، نويسنده , , Sheryl L. Santoro، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
2771
To page
2774
Abstract
The stereoselective synthesis of two novel series of tribasic macrocyclic antibiotics with potent in vitro activity against Pasteurella multocida and Escherichia coli strains of bacteria is described. The in vitro activity can be significantly influenced by the nature of the substituents on the C-4″ aminoalcohol, with the stereochemistry of the C-4″ alcohol playing a less critical role. The effect of substitution and stereochemistry on the in vivo activity in a murine model of respiratory infection is also described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792539
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