Author/Authors :
Youichi Shinozaki، نويسنده , , Narihiko Fukamiya، نويسنده , , Chieko Uchiyama، نويسنده , , Masayoshi Okano، نويسنده , , Kiyoshi Tagahara، نويسنده , , Kenneth F. Bastow، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Abstract :
Twelve taxane diterpenes (1–12), which were isolated previously from the EtOH extract of the aerial parts of Taxus yunnanensis or Taxus chinensis, were evaluated for cytotoxicity against the multidrug resistant cancer cells KB-VIN and KB-7d. Compounds 10 and 11 showed significant cytotoxicity in these cell lines. Compounds 3 and 12 also demonstrated significant activity against KB-7d. The biflavonoid 13 isolated from T. yunnanensis was only marginally cytotoxic against the A549 (lung) cell line, but a simple methoxylated analogue (14) was inactive.
