Author/Authors :
Kristel Senten، نويسنده , , Pieter Van der Veken، نويسنده , , Gunther Bal، نويسنده , , Ingrid De Meester، نويسنده , , Anne-Marie Lambeir، نويسنده , , Simon Scharpe، نويسنده , , Brigitte Bauvois، نويسنده , , Achiel Haemers، نويسنده , , Koen Augustyns، نويسنده ,
Abstract :
Structure–activity investigations of product-like dipeptide analogues lacking the C-terminal carbonyl function resulted in potent and selective dipeptidyl peptidase II (DPP II) inhibitors. Dab-Pip has an IC50=0.13 μM for DPP II and a 7600-fold selectivity with respect to DPP IV. This compound will be highly valuable for the investigation of the biochemical function of DPP II.
