Author/Authors :
Roger A. Smith، نويسنده , , Jinshan Chen، نويسنده , , Mary M. Mader، نويسنده , , Ingo Muegge، نويسنده , , Ulrike Moehler، نويسنده , , Suresh Katti، نويسنده , , Diana Marrero، نويسنده , , William G. Stirtan، نويسنده , , Daniel R. Weaver، نويسنده , , Hong Xiao، نويسنده , , William Carley، نويسنده ,
Abstract :
A library of benzofurans was prepared by solid-phase synthesis methods, and several analogues were identified as potent ligands for the estrogen receptors ER-α and ER-β, with some compounds having selectivity for ER-α. Analogues designed to more closely mimic Raloxifene were less effective. Certain benzofurans were effective in a bone pit assay, but were characterized as agonists in a MCF-7 breast tumor cell proliferation assay.
