Author/Authors :
Allan Wissner، نويسنده , , M. Brawner Floyd، نويسنده , , Sridhar K. Rabindran، نويسنده , , Ramaswamy Nilakantan، نويسنده , , Lee M. Greenberger، نويسنده , , Meng-Ru Shen، نويسنده , , Yu-Fen Wang، نويسنده , , Hwei-Ru Tsou، نويسنده ,
Abstract :
The syntheses and biological evaluations of 4-anilinoquinoline-3-carbonitrile analogues of the three clinical lead 4-anilinoquinazolines Iressa™, Tarceva™, and CI-1033 are described. The EGFR and HER-2 kinase inhibitory activities and the cell growth inhibition of the two series are compared with each other and with the clinical lead EKB-569. Similar activities are observed between these two series.
