Title of article
Syntheses and EGFR and HER-2 kinase inhibitory activities of 4-anilinoquinoline-3-carbonitriles: analogues of three important 4-anilinoquinazolines currently undergoing clinical evaluation as therapeutic antitumor agents
Author/Authors
Allan Wissner، نويسنده , , M. Brawner Floyd، نويسنده , , Sridhar K. Rabindran، نويسنده , , Ramaswamy Nilakantan، نويسنده , , Lee M. Greenberger، نويسنده , , Meng-Ru Shen، نويسنده , , Yu-Fen Wang، نويسنده , , Hwei-Ru Tsou، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
5
From page
2893
To page
2897
Abstract
The syntheses and biological evaluations of 4-anilinoquinoline-3-carbonitrile analogues of the three clinical lead 4-anilinoquinazolines Iressa™, Tarceva™, and CI-1033 are described. The EGFR and HER-2 kinase inhibitory activities and the cell growth inhibition of the two series are compared with each other and with the clinical lead EKB-569. Similar activities are observed between these two series.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792566
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