Title of article
Targeting thrombin and factor VIIa: design, synthesis, and inhibitory activity of functionally relevant indolizidinones
Author/Authors
Stephen Hanessian، نويسنده , , Eric Therrien، نويسنده , , Kenneth Granberg، نويسنده , , Ingemar Nilsson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
5
From page
2907
To page
2911
Abstract
Guided by molecular modeling, docking experiments, and available X-ray crystal structure data on the serine protease Factor VIIa and thrombin, a series of indolizidinone derivatives was designed and synthesized having diverse functionality at the P1, P2, and P3 sites.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792568
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