Author/Authors :
Maria Altamura، نويسنده , , Franca Canfarini، نويسنده , , Rose-Marie Catalioto، نويسنده , , Antonio Guidi، نويسنده , , Franco Pasqui، نويسنده , , Anna R. Renzetti، نويسنده , , Antonio Triolo، نويسنده , , Carlo A. Maggi، نويسنده ,
Abstract :
Non peptide products have been found to show nanomolar binding and functional affinities at the human tachykinin NK-2 receptor. The new antagonists do not possess stereogenic centers and their thermal behaviour in solution is featured by a peculiar set of conformational stereoisomers. A macroscopic viewpoint is preferentially adopted to rationalize the obtained results.
