Author/Authors :
Harriet W. Hamilton، نويسنده , , Gisele Nishiguchi، نويسنده , , Susan E. Hagen، نويسنده , , John D. Domagala، نويسنده , , Peter C. Weber MD، نويسنده , , Stephen Gracheck، نويسنده , , Stefanie L. Boulware، نويسنده , , Eric C. Nordby، نويسنده , , Hidetsura Cho، نويسنده , , Takeshi Nakamura، نويسنده , , Satoru Ikeda، نويسنده , , Wataru Watanabe، نويسنده ,
Abstract :
A series of novel benzthiodiazepinones was studied as antiherpetic agents. Significant improvements in potency and therapeutic index in a viral replication assay were realized over the starting molecule. The role of stereospecific substitution on the diazepine ring and optimal nitrogen substitution were investigated.
