Title of article
Novel Benzthiodiazepinones as antiherpetic agents: SAR improvement of therapeutic index by alterations of the seven-membered ring
Author/Authors
Harriet W. Hamilton، نويسنده , , Gisele Nishiguchi، نويسنده , , Susan E. Hagen، نويسنده , , John D. Domagala، نويسنده , , Peter C. Weber MD، نويسنده , , Stephen Gracheck، نويسنده , , Stefanie L. Boulware، نويسنده , , Eric C. Nordby، نويسنده , , Hidetsura Cho، نويسنده , , Takeshi Nakamura، نويسنده , , Satoru Ikeda، نويسنده , , Wataru Watanabe، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
2981
To page
2983
Abstract
A series of novel benzthiodiazepinones was studied as antiherpetic agents. Significant improvements in potency and therapeutic index in a viral replication assay were realized over the starting molecule. The role of stereospecific substitution on the diazepine ring and optimal nitrogen substitution were investigated.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792583
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