Title of article
Novel semi-synthetic glycopeptide antibiotics active against methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE): doubly-modified water-soluble derivatives of chloroorienticin B
Author/Authors
Osamu Yoshida، نويسنده , , Tatsuro Yasukata، نويسنده , , Yukihito Sumino، نويسنده , , Tadashi Munekage، نويسنده , , Yukitoshi Narukawa، نويسنده , , Yasuhiro Nishitani، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
5
From page
3027
To page
3031
Abstract
A series of N-alkylated and aminomethylated derivatives of chloroorienticin B, a vancomycin-related glycopeptide antibiotic, were synthesized. Doubly-modified derivatives having both hydrophobic and hydrophilic substituents exhibited potent antibacterial activity against MRSA and VRE along with considerable water-solubility.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792592
Link To Document