Title of article
Retro-Binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity
Author/Authors
Edwin J. Iwanowicz، نويسنده , , S. David Kimball، نويسنده , , Ming-Ji James Lin، نويسنده , , Wan F. Lau، نويسنده , , W. -S. Han، نويسنده , , Tammy C. Wang، نويسنده , , Daniel G. M. Roberts، نويسنده , , W. A. Schumacher، نويسنده , , Martin L. Ogletree، نويسنده , , Steven M. Seiler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
3183
To page
3186
Abstract
A series of retro-binding inhibitors of human α-thrombin was prepared to elucidate structure–activity relationships (SAR) and optimize in vivo performance. Compounds 9 and 11, orally active inhibitors of thrombin catalytic activity, were identified to be efficacious in a thrombin-induced lethality model in mice.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792628
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