Author/Authors :
Yoshitomo Suhara، نويسنده , , Atsushi Kittaka، نويسنده , , Seishi Kishimoto، نويسنده , , Martin J. Calverley، نويسنده , , Toshie Fujishima، نويسنده , , Nozomi Saito، نويسنده , , Takayuki Sugiura، نويسنده , , Keizo Waku، نويسنده , , Hiroaki Takayama، نويسنده ,
Abstract :
The 2α-methyl-, 2α-(3-hydroxypropyl)-, and 2α-(3-hydroxypropoxy)-derivatives of the ‘double side chain’ analogue of 1α,25-dihydroxyvitamin D3 were synthesized using Trost A-ring/CD-ring connective strategy. Regarding the requisite A-ring building blocks, a new, high yield and stereoselective route to the 2α-methyl compound starting from -glucose was developed. All three new analogues showed potent HL-60 cancer cell differentiation activity.
