Title of article
Facilely accessible multidrug resistance modulator derived from sucrose
Author/Authors
Nobutoshi Murakami، نويسنده , , Satoru Tamura، نويسنده , , Etsuko Iwata، نويسنده , , Shunji Aoki، نويسنده , , Shin-ichi Akiyama، نويسنده , , Motomasa Kobayashi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
3267
To page
3270
Abstract
Exploration for new MDR-modulators utilizing atractysucroses as scaffolds disclosed 2,3,4,3′,4′-O-pentaisovalerylsucrose (9) as a readily accessible medicinal lead. This lead was prepared from sucrose in 65% total yield for three steps. In addition, compound 9 exhibited more potent MDR modulating activity than verapamil, a representative modulator of MDR mediated by P-gp.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792647
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