Title of article
Synthesis and evaluation of water-Soluble paclitaxel prodrugs
Author/Authors
Xia Feng، نويسنده , , Ying-Jin Yuan، نويسنده , , Jin-Chuan Wu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
3301
To page
3303
Abstract
A series of water-soluble 2′-paclitaxel prodrugs were synthesized by attaching paclitaxel to polyethylene glycol (PEG) through amino acid spacers. The prodrugs showed highly improved water solubility, enhanced in vitro cytotoxicity and in vivo antitumor activity compared with the native drug, paclitaxel.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792655
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