Author/Authors :
T. G. Murali Dhar، نويسنده , , Zhongqi Shen، نويسنده , , Catherine A. Fleener، نويسنده , , Katherine A. Rouleau، نويسنده , , Joel C. Barrish، نويسنده , , Diane L. Hollenbaugh، نويسنده , , Edwin J. Iwanowicz، نويسنده ,
Abstract :
A modified approach to the synthesis of 3-(oxazolyl-5-yl) indoles is reported. This method was applied to the synthesis of series of novel indole based inhibitors of inosine monophosphate dehydrogenase (IMPDH). The synthesis and the structure–activity relationships (SARs), derived from in vitro studies, for this new series of inhibitors is given.
