Title of article
The TosMIC approach to 3-(Oxazol-5-yl) indoles: application to the synthesis of indole-based IMPDH inhibitors
Author/Authors
T. G. Murali Dhar، نويسنده , , Zhongqi Shen، نويسنده , , Catherine A. Fleener، نويسنده , , Katherine A. Rouleau، نويسنده , , Joel C. Barrish، نويسنده , , Diane L. Hollenbaugh، نويسنده , , Edwin J. Iwanowicz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
3305
To page
3308
Abstract
A modified approach to the synthesis of 3-(oxazolyl-5-yl) indoles is reported. This method was applied to the synthesis of series of novel indole based inhibitors of inosine monophosphate dehydrogenase (IMPDH). The synthesis and the structure–activity relationships (SARs), derived from in vitro studies, for this new series of inhibitors is given.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792656
Link To Document