Title of article
Novel human histamine H3 receptor antagonists
Author/Authors
Chandra Shah، نويسنده , , Laura McAtee، نويسنده , , J. Guy Breitenbucher، نويسنده , , Dale Rudolph، نويسنده , , Xiaobing Li، نويسنده , , Timothy W. Lovenberg، نويسنده , , Curt Mazur، نويسنده , , Sandy J. Wilson، نويسنده , , Nicholas I. Carruthers، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
3309
To page
3312
Abstract
High throughput screening, using the recombinant human H3 receptor, was used to identify novel histamine H3 receptor antagonists. Evaluation of the lead compounds ultimately afforded potent, selective, orally bioavailable compounds (e.g., 38) with favorable blood–brain barrier penetration.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792657
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