Title of article :
Scaleable and efficient synthesis of 2′-deoxy-2′-N-phthaloyl nucleoside phosphoramidites for oligonucleotide synthesis
Author/Authors :
Alexander Karpeisky، نويسنده , , David Sweedler، نويسنده , , Peter Haeberli، نويسنده , , Javier Read، نويسنده , , Keith Jarvis، نويسنده , , Leonid Beigelman، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2002
Pages :
3
From page :
3345
To page :
3347
Abstract :
2′-Deoxy-2′-N-phthaloyl nucleosides were prepared from arabino nucleosides by triflate displacement with phthalimide in the presence of DBU. The corresponding phosphoramidites suitable for automated oligonucleotide synthesis were also synthesized. The scalability of described procedures was demonstrated on a 100-g scale preparation of 2′-deoxy-2′-amino-C phosphoramidite.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2002
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
792666
Link To Document :
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