Author/Authors :
Vishnu Vardhan Karnati، نويسنده , , Xingming Gao، نويسنده , , Shouhai Gao، نويسنده , , Wenqian Yang، نويسنده , , Weijuan Ni، نويسنده , , Sabapathy Sankar، نويسنده , , Binghe Wang، نويسنده ,
Abstract :
A glucose selective diphenylboronic acid fluorescent sensor (10a) with a Ka of 1472 M−1 has been synthesized and evaluated. This sensor shows a 43- and 49-fold selectivity for glucose over fructose and galactose, respectively. The binding affinity improvement is about 300-fold and the selectivity improvement for glucose over fructose is about 1400-fold compared with the monoboronic acid compound, phenylboronic acid. 1H NMR studies indicate that sensor 10a binds with α- -glucofuranose in a bidentate manner (1:1 ratio).
