Title of article
Design and synthesis of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one derivatives as cysteine proteases inhibitors
Author/Authors
Nian E. Zhou، نويسنده , , Deqi Guo، نويسنده , , Jadwiga Kaleta، نويسنده , , Enrico Purisima، نويسنده , , Robert Menard، نويسنده , , Ronald G. Micetich، نويسنده , , Rajeshwar Singh، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
3413
To page
3415
Abstract
A series of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one compounds was designed and synthesized as a new class of inhibitors for cysteine proteases cathepsins B, L, K, and S. One compound (5S,6S)-6-(N-benzyloxycarbonyl- -phenylalanyl) amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one showed excellent cathepsin L and K inhibition activity with IC50 at a low nanomolar range.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792681
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