Title of article
Novel spirocyclic pyrrolidones as P2/P1 mimetics in potent inhibitors of HIV-1 protease
Author/Authors
Wieslaw M. Kazmierski، نويسنده , , Eric Furfine، نويسنده , , Andrew Spaltenstein، نويسنده , , Lois L. Wright، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
3431
To page
3433
Abstract
We have developed concise and efficient syntheses of novel spirocyclic pyrrolidones 1–3, which involve the alkylation of pyrrolidone precursor 13 with 1,5-dibromopentane, 16 and 15, followed by an in situ lactamization. Conjugates of 1 and 2 with P1′/P2′ hydroxy-indanolamine moiety resulted in novel and potent inhibitors of HIV-1 protease 25 and 26, suggesting that 1 and 2 are novel P2/P1 HIV-PI mimetics.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792685
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