• Title of article

    Six-membered cyclic ureas as HIV-1 protease inhibitors: A QSAR study based on CODESSA PRO approach

  • Author/Authors

    Alan R. Katritzky، نويسنده , , Alexander Oliferenko، نويسنده , , Andre Lomaka، نويسنده , , Mati Karelson، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2002
  • Pages
    5
  • From page
    3453
  • To page
    3457
  • Abstract
    Quantitative structure–activity relationships (QSAR) for HIV-1 protease inhibitory activity of substituted tetrahydropyrimidinones have been produced using CODESSA PRO methodology and software. The best four-parameter equation (R2cv=0.847) allowed us to reveal two main structural factors which are strongly correlated with the title activity: molecular hydrophobicity and ability to form hydrogen bonds with the target enzyme.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2002
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    792690

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=792690