Title of article
Reductively activated disulfide prodrugs of paclitaxel
Author/Authors
Vivekananda M. Vrudhula، نويسنده , , John F. MacMaster، نويسنده , , Zhengong Li، نويسنده , , David E. Kerr، نويسنده , , Peter D. Senter، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
4
From page
3591
To page
3594
Abstract
A series of unsymmetrical polar disulfide prodrugs 2–5 of paclitaxel were designed and synthesized as reductively activated prodrugs. These compounds behaved as prodrugs in vitro on L2987 lung carcinoma cells. In vivo evaluation in mice demonstrated that the mutual prodrug 5 with captopril exhibited significant regressions and cures.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2002
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792721
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