Author/Authors :
David R. Luthin، نويسنده , , Yufeng Hong، نويسنده , , Eileen Tompkins، نويسنده , , Kenna L. Anderes، نويسنده , , Genevieve Paderes، نويسنده , , Eugenia A. Kraynov، نويسنده , , Mary A. Castro، نويسنده , , Karen D. Nared-Hood، نويسنده , , Rosemary Castillo، نويسنده , , Margaret Gregory، نويسنده , , Haresh Vazir، نويسنده , , John M. May، نويسنده , , Mark B. Anderson، نويسنده ,
Abstract :
A novel series of derivatives of mono- and diaminopyrimidines 1 potently displaced binding of a radiolabeled GnRH analogue to human and rat GnRH receptors. Analogues from these series competitively antagonized GnRH-stimulated increases in extracellular acidification in vitro and suppressed GnRH-mediated increases in circulating luteinizing hormone (LH) in castrated rats and testosterone in intact rats. These compounds or their analogues may be useful in treating sex hormone-dependent disease.
