Title of article
Design and synthesis of pseudo-Symmetric HIV protease inhibitors containing a novel hydroxymethylcarbonyl (HMC)-Hydrazide isostere
Author/Authors
Koushi Hidaka، نويسنده , , Tooru Kimura، نويسنده , , Yoshio Hayashi، نويسنده , , Keith F. McDaniel، نويسنده , , Tatyana Dekhtyar، نويسنده , , Lynn Colletti، نويسنده , , Yoshiaki Kiso، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
93
To page
96
Abstract
Pseudo-symmetric HIV-1 protease inhibitors containing a novel HMC-hydrazide isostere as the transition-state mimic were designed and synthesized. Most of the synthetic compounds with varied structures at the P and P′ sites around this core unit showed potent inhibitory activity against HIV-1 protease with nanomolar Ki values.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792867
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