Title of article
Imidazo[4,5-c]pyridines as corticotropin releasing factor receptor ligands
Author/Authors
Argyrios G. Arvanitis، نويسنده , , Joseph T. Rescinito، نويسنده , , Charles R. Arnold، نويسنده , , Richard G. Wilde، نويسنده , , Lawrence W. Fitzgerald، نويسنده , , Robert Zaczek، نويسنده , , Paul R. Hartig، نويسنده , , Scott Grossman، نويسنده , , Stephen P. Arneric، نويسنده , , Paul J. Gilligan، نويسنده , , Richard E. Olson، نويسنده , , David W. Robertson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
3
From page
129
To page
131
Abstract
A series of high affinity CRF receptor ligands with an imidazo[4,5-c]pyridine core is described. Individual analogues were synthesized and tested in vitro in rat brain receptors to determine binding affinity. The best compound was further tested in the dog N-in-1 pharmacokinetic model to assess oral bioavailability at 1 mg/kg po.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792875
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