Title of article
New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 3
Author/Authors
Yasuyuki Takeda، نويسنده , , Toshiharu Yoshino، نويسنده , , Kouichi Uoto، نويسنده , , Jun Chiba، نويسنده , , Takashi Ishiyama، نويسنده , , Michio Iwahana، نويسنده , , Takeshi Jimbo، نويسنده , , Noriko Tanaka، نويسنده , , Hirofumi Terasawa، نويسنده , , Tsunehiko Soga، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
6
From page
185
To page
190
Abstract
We synthesized novel water-soluble and orally active taxane analogues, 7-deoxy-9β-dihydro-9,10-O-acetal taxanes. Cytotoxicities of the synthetic compounds were greater than those of paclitaxel and docetaxel, especially against resistant cancer cell lines expressing P-glycoprotein. In addition, some compounds showed potent antitumor effects against B16 melanoma BL6 in vivo by both iv and po administration.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792887
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