Title of article
Methylphosphonate LNA: a locked nucleic acid with a methylphosphonate linkage
Author/Authors
Anne Lauritsen، نويسنده , , Britta M. Dahl، نويسنده , , Otto Dahl، نويسنده , , Birte Vester، نويسنده , , Jesper Wengel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
253
To page
256
Abstract
Synthesis of an oligonucleotide containing one methylphosphonate locked nucleic acid (LNA) thymine monomer using the phosphoramidite approach is described. The binding affinity of this 9-mer methylphosphonate LNA towards complementary DNA and RNA oligonucleotides was increased compared to the reference DNA, but decreased compared to the reference LNA. In the 9-mer sequence context studied, introduction of a single methylphosphonate LNA monomer, contrary to a single LNA monomer, efficiently inhibits 3′-exonucleolytic degradation.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792900
Link To Document