Title of article
Development of a presynaptic 5-HT1A antagonist
Author/Authors
Ronald J. Mattson، نويسنده , , John D. Catt، نويسنده , , Charles P. Sloan، نويسنده , , Qi Gao، نويسنده , , Richard B. Carter، نويسنده , , Anthony Gentile، نويسنده , , Cathy D. Mahle، نويسنده , , F. Fatima Matos، نويسنده , , Rachel McGovern، نويسنده , , Cam P. VanderMaelen، نويسنده , , Frank D. Yocca، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
285
To page
288
Abstract
A new 5-HT1A silent antagonist 14 (5-HT1A IC50=2.2 nM) antagonizes the effects of agonists on reciprocal forepaw treading behavior, on neuronal firing in the rat dorsal raphé, and on 5-HT1A release in the raphé and hippocampus. While 14 alone was inactive in the social interaction paradigm, it completely reversed the social interaction activity of the serotonergic compounds (buspirone, 1, and 2).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792908
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