Author/Authors :
Kenneth C. Rupert، نويسنده , , James R. Henry، نويسنده , , John H. Dodd، نويسنده , , Scott A. Wadsworth، نويسنده , , Druie E. Cavender، نويسنده , , Gilbert C. Olini، نويسنده , , Bohumila Fahmy، نويسنده , , John J. Siekierka، نويسنده ,
Abstract :
The MAP kinase p38 is implicated in the release of the pro-inflammatory cytokines TNF-α and IL-1β. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohnʹs disease. A novel series of imidazopyrimidines have been discovered that potently inhibit p38 and suppress the production of TNF-α in vivo.
