Title of article
2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors
Author/Authors
Yung Hyup Joo، نويسنده , , Jin-Kwan Kim، نويسنده , , Seon-Hwa Kang، نويسنده , , Min-Soo Noh، نويسنده , , Jun-Yong Ha، نويسنده , , Jin Kyu Choi، نويسنده , , Kyung-Min Lim، نويسنده , , Chang Hoon Lee، نويسنده , , Chia-Shin Chung، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
413
To page
417
Abstract
A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792935
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