Author/Authors :
Michael G. Thomas، نويسنده , , Chris Lawson، نويسنده , , Nigel M. Allanson، نويسنده , , Bruce W. Leslie، نويسنده , , Joanna R. Bottomley، نويسنده , , Andrew McBride، نويسنده , , Oyinkan A. Olusanya، نويسنده ,
Abstract :
A series of 2(Z)-2-benzylidene-6,7-dihydroxybenzofuran-3[2H]-ones was identified as potent inhibitors of bacterial chorismate synthase. The 2′-hydroxy-4′-pentoxy analogue 33 is a potent inhibitor of Streptococcus pneumoniae chorismate synthase.
