Author/Authors :
Joachim Mittendorf، نويسنده , , Franz Kunisch، نويسنده , , Michael Matzke، نويسنده , , Hans-Christian Militzer، نويسنده , , Axel Schmidt، نويسنده , , Wolfgang Sch?nfeld، نويسنده ,
Abstract :
A series of novel β-amino acids has been synthesized and tested for their in vitro antifungal activity against Candida albicans. A steep SAR was observed. β-Amino acid 21 (BAY 10-8888/PLD-118) revealed the most favourable activity–tolerability profile and was selected for clinical studies as a novel antifungal for the oral treatment of yeast infections.
