Title of article
Characterization of the mechanism of anticonvulsant activity for a selected set of putative AMPA receptor antagonists
Author/Authors
Silvana Grasso، نويسنده , , Nicola Micale، نويسنده , , Maria Zappalà، نويسنده , , Alessandro Galli، نويسنده , , Chiara Costagli، نويسنده , , Frank S. Menniti، نويسنده , , Carlo De Micheli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
443
To page
446
Abstract
A selected set of 1-aryl-7,8-methylenedioxy-2,3-benzodiazepin-4-ones and their analogues were evaluated for their ability to bind the competitive and noncompetitive sites of the AMPA receptors complex as well as to the glycine site of the NMDA receptors. The results put in evidence that most of the test compounds, despite a close structural similarity with GYKI 52466, possess a significantly different pharmacological profile.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792941
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