Author/Authors :
Colin M. Tice، نويسنده , , Robert E. Hormann، نويسنده , , Christine S. Thompson، نويسنده , , Jennifer L. Friz، نويسنده , , Caitlin K. Cavanaugh، نويسنده , , Enrique L. Michelotti، نويسنده , , Javier Garcia، نويسنده , , Ernesto Nicolas، نويسنده , , Fernando Albericio، نويسنده ,
Abstract :
A lead discovery library and a follow-up focused library of α-acylaminoketones were designed based on known dibenzoylhydrazine ecdysone agonists, including GS™–E. The compounds were assayed in mammalian cells expressing the ecdysone receptor from Bombyx mori for their ability to cause expression of a reporter gene downstream of an ecdysone response element. The most potent α-acylaminoketones were comparable to GS™–E in this assay.
