Title of article
Thiophene-based vitronectin receptor antagonists
Author/Authors
Monica Bubenik، نويسنده , , Karen Meerovitch، نويسنده , , Frederic Bergeron، نويسنده , , Giorgio Attardo، نويسنده , , Laval Chan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
503
To page
506
Abstract
A series of αvβ3 antagonists based on a thiophene scaffold were synthesized via two routes and evaluated for in vitro biological activity. We have identified several structurally similar antagonists with different selectivities towards αIIbβ3, αvβ5 and α5β1 at the cellular level. In addition, these antagonists exerted an antiangiogenic effect in the chick chorioallantoic membrane (CAM) assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792954
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