Title of article
Cephalosporin prodrugs of paclitaxel for immunologically specific activation by L-49-sFv-β-Lactamase fusion protein
Author/Authors
Vivekananda M. Vrudhula، نويسنده , , David E. Kerr، نويسنده , , Nathan O. Siemers، نويسنده , , Gene M. Dubowchik، نويسنده , , Peter D. Senter، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
539
To page
542
Abstract
Paclitaxel conjugates of 7-phenylacetamidocephalosporanic acid were prepared as prodrugs for site specific activation by targeted β-lactamase. Immunologically specific activation of the prodrug 5 containing 3,3-dimethyl-4-amino-butyric acid as linker in combination with the fusion protein L-49-sFv-β-lactamase was demonstrated in vitro on 3677 melanoma cells.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792961
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