Title of article
Quinolone-Based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues
Author/Authors
T. G. Murali Dhar، نويسنده , , Scott H. Watterson، نويسنده , , Ping Chen، نويسنده , , Zhongqi Shen، نويسنده , , Henry H. Gu، نويسنده , , Derek Norris، نويسنده , , Marianne Carlsen، نويسنده , , Kristin D. Haslow، نويسنده , , William J. Pitts، نويسنده , , Junqing Guo، نويسنده , , John Chorba، نويسنده , , Catherine A. Fleener، نويسنده , , Katherine A. Rouleau، نويسنده , , Robert Townsend، نويسنده , , Diane Hollenbaugh، نويسنده , , Edwin J. Iwanowicz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
5
From page
547
To page
551
Abstract
The synthesis and the structure–activity relationships (SAR) of analogues derived from the introduction of basic residues on ring D of quinolone–based inhibitors of IMPDH are described. This led to the identification of compound 27 as a potent inhibitor of IMPDH with significantly improved aqueous solubility over the lead compound 1.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792963
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