Author/Authors :
Sang-sup Jew، نويسنده , , Boon Saeng Park، نويسنده , , Doo-yeon Lim، نويسنده , , Myoung Goo Kim، نويسنده , , In Kwon Chung، نويسنده , , Joo Hee Kim، نويسنده , , Chung Il Hong، نويسنده , , Joon-Kyum Kim، نويسنده , , Hong-Jun Park، نويسنده , , Jun-Hee Lee، نويسنده , , Hyeung-geun Park، نويسنده ,
Abstract :
Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.
