• Title of article

    Identification of a High-Affinity Phosphopeptide Inhibitor of Stat3

  • Author/Authors

    Zhiyong Ren، نويسنده , , Larry A. Cabell، نويسنده , , Timothy S. Schaefer، نويسنده , , John S. McMurray، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2003
  • Pages
    4
  • From page
    633
  • To page
    636
  • Abstract
    Stat3 is a latent transcription factor that exhibits elevated activity in a variety of human cancers. To find a lead peptide for peptidomimetic drug development we synthesized and tested phosphopeptides derived from known receptor docking sites and found Y(p)LPQTV as the optimal sequence. SAR studies showed that each residue from pY to pY+3 provided binding energy.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2003
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    792981

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=792981