Title of article :
Synthesis and preliminary biological evaluation of 6-O-[11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT
Author/Authors :
Xuan Liu، نويسنده , , Qi-Huang Zheng، نويسنده , , Xiangshu Fei، نويسنده , , Ji-Quan Wang، نويسنده , , David W. Ohannesian، نويسنده , , Leonard C. Erickson، نويسنده , , K. Lee Stone، نويسنده , , Gary D. Hutchins، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
Novel radiolabeled O6-benzylguanine derivatives, 6-O-[11C]-[(methoxymethyl)benzyl]guanines ([11C]p-O6-MMBG, 1a; [11C]m-O6-MMBG, 1b; ([11C]o-O6-MMBG, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) breast cancer imaging agents for DNA repair protein, O6-alkylguanine-DNA alkyltransferase (AGT).
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
