Title of article
Protective effect of imidazolopyrazinone antioxidants on ischemia/reperfusion injury
Author/Authors
Axelle Arrault، نويسنده , , Marlène Dubuisson، نويسنده , , Sonia Gharbi، نويسنده , , Cécile Marchand، نويسنده , , Tony Verbeuren، نويسنده , , Alain Rupin، نويسنده , , Alex Cordi، نويسنده , , Eliete Bouskela، نويسنده , , Jean-François Rees، نويسنده , , Jacqueline Marchand-Brynaert، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
653
To page
656
Abstract
A series of 2-substituted 3,7-dihydroimidazolo[1,2-a]pyrazine-3-ones has been synthesized and evaluated for their antioxidant activity. Compounds 1–8 are inhibitors of AAPH-induced lipid peroxidation (in vitro) and excellent protectors against microvascular damages in ischemia/reperfusion (in vivo). Hence, the bicyclic structure typical of coelenterazine (luciferin) could be considered as a useful lead in medicinal chemistry.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792986
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