Author/Authors :
Anandan Palani، نويسنده , , Sherry Shapiro، نويسنده , , John W. Clader، نويسنده , , William J. Greenlee، نويسنده , , Susan Vice، نويسنده , , Stuart McCombie، نويسنده , , Kathleen Cox، نويسنده , , Julie Strizki، نويسنده , , Bahige M. Baroudy، نويسنده ,
Abstract :
The synthesis, SAR and biological evaluation of symmetrical amide analogues of our clinical candidate SCH 351125 are described. A series of potent and orally bioavailable CCR5 antagonists containing symmetrical 2,6-dimethyl isonicotinamides and 2, 6-dimethyl pyrimidines amides were generated with enhanced affinity for the CCR5 receptor.
