Title of article
Oximino-piperidino-piperidine-based CCR5 antagonists. Part 2: synthesis, SAR and biological evaluation of symmetrical heteroaryl carboxamides
Author/Authors
Anandan Palani، نويسنده , , Sherry Shapiro، نويسنده , , John W. Clader، نويسنده , , William J. Greenlee، نويسنده , , Susan Vice، نويسنده , , Stuart McCombie، نويسنده , , Kathleen Cox، نويسنده , , Julie Strizki، نويسنده , , Bahige M. Baroudy، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
4
From page
709
To page
712
Abstract
The synthesis, SAR and biological evaluation of symmetrical amide analogues of our clinical candidate SCH 351125 are described. A series of potent and orally bioavailable CCR5 antagonists containing symmetrical 2,6-dimethyl isonicotinamides and 2, 6-dimethyl pyrimidines amides were generated with enhanced affinity for the CCR5 receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2003
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
792999
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